Four eastbound lanes of the U.S. 60 were re-opened after more than an hour Sunday afternoon at Stapley Drive following a vehicle rollover.
At least two people were taken to area hospitals with non life-threatening injuries, according to authorities.
No further information on the people injured or the extent of injuries was immediately available Sunday. The lanes were closed after the 11:45 a.m. incident to clear debris, according to authorities.
According to Mesa police, one person was trapped in the vehicle before being rescued.
Arizona Department of Public Safety officials are investigating the incident.